Associate Professor Ph.D Elena Ionică
Faculty of Biology, University of Bucharest, RO
Prof. Ionica is interested on signaling pathways on colorectal cancer pathology, and she was focused on discovering the correlation between gene and protein expression (by LOH and MSI/ MLPA, immunofluorescence) with the goal of correlate phenotype-genotype expression of most important proteins involved in colorectal tumorigenesis, for clarifying the crosstalk of interested genes and to better understand the CRC typology among Romanian patients.
Together with her colleagues, she has begun to develop experimental models to i) modulate the communication between the normal and tumoral cells by nanostructures functionalized with specific inhibitors for Notch non-canonical pathway; ii) develop an adjuvant therapy for colon adenocarcinomas by using the cross-link between anti-inflammatory drug and probiotics that are smart delivery by specific nanostructure; iii) evaluate the role of inflammation in the nutrient’s absorption process. In 2004, the group interest was enlarged toward neuromuscular disorders, with the goal of introducing in Romania the performance tests of molecular screening, for identifying the specific gene mutations and its expression at patients with neuromuscular disorders and at their relatives.
For the first time in Romania, were implemented molecular techniques (MMLPA, High Resolution –Melting Curve Analysis and sequencing) and immunohistochemistry for analyzing the correlation between protein and gene expression at DMD/ BMD Romanian patients.
The research results were transferred in health services, and at this moment, it represents the only one group which can make proteomics and genomics diagnoses in Romania, with genotype/ phenotype correlation.
The results of research activity were presented at national and international conferences and published in journals with references.